Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.57 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7629159 | 0.91 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL7207092 | 0.81 | PTGS2 (0.63) | PTGS2GPR17PTGS1 | |
| SCHEMBL6170498 | 0.80 | PTGS2 (0.62) | PTGS2GPR17PTGS1 | |
| SCHEMBL6170584 | 0.80 | PTGS2 (0.62) | PTGS2GPR17PTGS1 | |
| SCHEMBL6169260 | 0.80 | PTGS2 (0.59) | PTGS2GPR17PTGS1 | |
| SCHEMBL6168345 | 0.80 | PTGS2 (0.56) | PTGS2GPR17PTGS1 | |
| SCHEMBL6170593 | 0.78 | PTGS2 (0.59) | PTGS2GPR17PTGS1 | |
| SCHEMBL8117014 | 0.78 | KDM4E (0.42) | — | |
| SCHEMBL6169004 | 0.78 | PTGS2 (0.60) | PTGS2GPR17 | |
| SCHEMBL7204095 | 0.77 | PTGS2 (0.60) | PTGS2GPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |