Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624531 | 0.98 | LMNA (0.35) | LMNA | |
| SCHEMBL4032726 | 0.95 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL4036851 | 0.95 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL4664028 | 0.95 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL4662577 | 0.95 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL4036849 | 0.95 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL7633240 | 0.91 | TDP1 (0.34) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL27743005 | 0.91 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL2778608 | 0.91 | LMNA (0.36) | LMNA | |
| SCHEMBL7630102 | 0.88 | TDP1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448247-B1 | TACHYKININ RECEPTOR ANTAGONIST; ESPECIALLY TO THE RECEPTORS FOR SUBSTANCE P (WHICH RECEPTORS ARE GENERALLY REFERRED TO AS ?NEUROKININ 1 RECEPTORS?) | SANKYO COMPANY, LIMITED (JP) | 2002-09-10 | — | — | US | disclosed |
| US-6159967-A | Heterocyclic compounds having tachykinin receptor antagonist activity their preparation and their use | SANKYO COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |
| CN-1157286-A | N,N-dimethyl-1-t-butoxycarbonyl-4-phenylpiperidine-4-carboxamide | SANKYO CO (JP) | 1997-08-20 | — | — | CN | disclosed |
| EP-0776893-A1 | Azaheterocyclic compounds having tachykinin receptor antagonist activity; Nk1 and NK2 | SANKYO COMPANY LIMITED (JP) | 1997-06-04 | — | — | EP | disclosed |