Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032726 | 1.00 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL4662577 | 1.00 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL4036849 | 1.00 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL4036851 | 1.00 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL27743005 | 0.95 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL7629403 | 0.95 | LMNA (0.33) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL7624531 | 0.93 | LMNA (0.35) | LMNA | |
| SCHEMBL9336248 | 0.91 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL2244973 | 0.91 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A | |
| SCHEMBL1069062 | 0.91 | LMNA (0.39) | LMNAMEN1THRBHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912983-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals, Inc. (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007021982-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-02-22 | — | — | WO | disclosed |