Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4750734 | 0.69 | CYP2C19 (0.48) | HIF1ASNCAALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL1680771 | 0.69 | CYP2C19 (0.48) | HIF1ASNCAALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL8331435 | 0.69 | SNCA (0.64) | HIF1ASNCAAPPALDH1A1CYP1A2 | |
| Bromide SCHEMBL15635739 | 0.68 | HIF1A (0.46) | HIF1ASNCAAPPALDH1A1CYP1A2 | |
| Bromide SCHEMBL2459236 | 0.67 | SNCA (0.56) | HIF1ASNCAAPPALDH1A1CYP1A2 | |
| Bromide SCHEMBL5963912 | 0.67 | HIF1A (0.40) | HIF1ASNCAAPPALDH1A1CYP1A2 | |
| Bromide SCHEMBL11344780 | 0.67 | TP53 (0.46) | HIF1ASNCAALDH1A1CYP2D6 | |
| Bromide SCHEMBL39844 | 0.66 | SNCA (0.73) | HIF1ASNCAAPPALDH1A1CYP1A2 | |
| Bromide SCHEMBL2446627 | 0.66 | HIF1A (0.55) | HIF1ASNCAAPPALDH1A1CYP1A2 | |
| Bromide SCHEMBL163158 | 0.66 | SNCA (0.67) | HIF1ASNCAAPPALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002002561-A1 | NOVEL 1β-METHYLCARBAPENEM DERIVATIVES AND PROCESS OF PREPARATION THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2002-01-10 | — | — | WO | disclosed |