Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | HTR1D | P28221 | 3/20 | 0.36 |
| ▸ | HTR1B | P28222 | 3/20 | 0.36 |
| ▸ | CPT2 | P23786 | 2/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742248 | 1.00 | MAPT (0.39) | MAPTALDH1A1LMNARXFP1HRH1 | |
| SCHEMBL763040 | 0.89 | MAPT (0.39) | MAPTALDH1A1LMNARXFP1HRH1 | |
| SCHEMBL2789481 | 0.87 | PARP1 (0.37) | MAPTALDH1A1PARP1DRD2DRD4 | |
| SCHEMBL738739 | 0.87 | HRH1 (0.46) | HRH1CYP2D6KCNH2CHRM1HTR2B | |
| SCHEMBL738740 | 0.87 | HRH1 (0.46) | HRH1CYP2D6KCNH2CHRM1HTR2B | |
| SCHEMBL742029 | 0.86 | NSD2 (0.36) | RXFP1DRD2DRD4DRD3 | |
| SCHEMBL742030 | 0.86 | NSD2 (0.36) | RXFP1DRD2DRD4DRD3 | |
| SCHEMBL741798 | 0.86 | LIPG (0.35) | RXFP1DRD2DRD4HTR1AHTR1D | |
| SCHEMBL741797 | 0.86 | LIPG (0.35) | RXFP1DRD2DRD4HTR1AHTR1D | |
| SCHEMBL742755 | 0.85 | HRH1 (0.39) | HRH1CYP2D6KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |