SCHEMBL7631063

SCHEMBL7631063

CCc1ccc(C(N)N(N)N)c(CC)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
MAPK1 P28482 1/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
BACE1 P56817 1/20 0.35
TRPA1 O75762 1/20 0.34
CYP2A6 P11509 2/20 0.33
CYP1A2 P05177 1/20 0.33
CA2 P00918 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
AKR1C3 P42330 1/20 0.32
AKR1C2 P52895 1/20 0.32
NOS3 P29474 1/20 0.32
NOS1 P29475 1/20 0.32
NOS2 P35228 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL538823 0.81 NPC1 (0.41) NPC1ALDH1A1LMNAMAPTMAPK1
SCHEMBL31206567 0.81 NPC1 (0.41) NPC1ALDH1A1LMNAMAPTMAPK1
Hydrochloric Acid SCHEMBL28833637 0.79 NPC1 (0.40) NPC1ALDH1A1LMNAMAPTMAPK1
SCHEMBL9735709 0.75 CYP1A2 (0.43) NPC1ALDH1A1LMNAMAPTMAPK1
SCHEMBL18243233 0.73 ALDH1A1 (0.41) NPC1ALDH1A1LMNAMAPTMAPK1
SCHEMBL7514265 0.72 TRPA1 (0.42) NPC1ALDH1A1LMNAMAPTMAPK1
SCHEMBL18242360 0.72 ALDH1A1 (0.40) NPC1ALDH1A1LMNAMAPTMAPK1
SCHEMBL18242755 0.70 ALDH1A1 (0.39) NPC1ALDH1A1LMNAMAPTMAPK1
SCHEMBL28806591 0.69 NPC1 (0.41) NPC1ALDH1A1LMNAMAPTMAPK1
SCHEMBL96518 0.69 ALDH1A1 (0.38) NPC1ALDH1A1LMNAMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1242518-A2 METHOD FOR PRODUCING SOFT TO SEMIRIGID POLYURETHANE INTEGRAL FOAMED MATERIALS Bayer Aktiengesellschaft (DE) 2002-09-25 EP disclosed
WO-2001044352-A2 METHOD FOR PRODUCING SOFT TO SEMIRIGID POLYURETHANE INTEGRAL FOAMED MATERIALS BAYER AKTIENGESELLSCHAFT (DE) 2001-06-21 WO disclosed