Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | PPIA | P62937 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BCL9 | O00512 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763816 | 0.93 | CTSB (0.36) | CTSBCTSSCTSKKCNH2HRH1 | |
| SCHEMBL16301209 | 0.92 | HRH1 (0.36) | CTSBCTSSCTSKKCNH2HRH1 | |
| SCHEMBL741591 | 0.92 | CTSB (0.35) | CTSBCTSSCTSKKCNH2HRH1 | |
| SCHEMBL741590 | 0.92 | CTSB (0.35) | CTSBCTSSCTSKKCNH2HRH1 | |
| SCHEMBL762504 | 0.92 | HRH1 (0.37) | CTSSCTSKHRH1CYP2D6HRH2 | |
| SCHEMBL742063 | 0.92 | KCNH2 (0.36) | KCNH2HRH1CYP2D6PPARAALDH1A1 | |
| SCHEMBL762607 | 0.91 | KLK5 (0.35) | CTSSCTSKKCNH2HRH1CYP2D6 | |
| SCHEMBL762785 | 0.90 | HRH1 (0.42) | CTSBCTSSCTSKKCNH2HRH1 | |
| SCHEMBL763177 | 0.89 | CTSB (0.36) | CTSBCTSSCTSKKCNH2HRH1 | |
| SCHEMBL762513 | 0.89 | KCNH2 (0.36) | CTSBCTSSCTSKKCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |