SCHEMBL7632402

SCHEMBL7632402

NC(=O)c1cc(=O)c2cccc(NC(=O)c3ccc4c(c3)CC(COCc3ccc(F)cc3)O4)c2o1

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 16/20 0.46
GPR55 Q9Y2T6 1/20 0.42
RAB9A P51151 1/20 0.38
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7632445 0.93 GPR35 (0.54) GPR35GPR55
SCHEMBL7634224 0.93 GPR35 (0.49) GPR35GPR55RAB9A
SCHEMBL7630922 0.90 GPR35 (0.49) GPR35GPR55RAB9AKMT2A
SCHEMBL7635670 0.89 GPR35 (0.42) GPR35GPR55RAB9A
SCHEMBL7625167 0.87 GPR35 (0.57) GPR35GPR55
SCHEMBL7627975 0.84 CYSLTR2 (0.41) GPR35
SCHEMBL7628839 0.83 GPR35 (0.47) GPR35GPR55RAB9AKMT2A
SCHEMBL7638126 0.82 GPR35 (0.45) GPR35GPR55RAB9A
SCHEMBL7626670 0.81 PRKDC (0.40) KMT2A
SCHEMBL7626681 0.81 PRKDC (0.40) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888327-B1 BENZOPYRAN DERIVATIVES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION MENARINI LAB (ES) 2002-06-12 EP disclosed
US-5990142-A ANTIINFLAMMATORY AGENTS AND ANTIALLERGENS HAVING GOOD ORAL ADSORPTION AND BIOAVAILABILITY; CARDIOTONIC AND ANTIISCHEMIC AGENTS LABORATORIOS MENARINI S.A. (ES) 1999-11-23 US disclosed