Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 5/20 | 0.68 |
| ▸ | GABBR1 | Q9UBS5 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL560490 | 0.98 | GABBR2 (0.66) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL8903793 | 0.91 | GABBR2 (0.57) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL1532918 | 0.90 | PRKCZ (0.54) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL560574 | 0.87 | GABBR2 (0.64) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| Hydrochloric Acid SCHEMBL560861 | 0.87 | GABBR2 (0.56) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL26231951 | 0.86 | GABBR2 (0.62) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL559899 | 0.86 | GABBR2 (0.62) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| Hydrochloric Acid SCHEMBL560273 | 0.84 | GABBR2 (0.60) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL560445 | 0.84 | GABBR2 (0.52) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| Hydrochloric Acid SCHEMBL559973 | 0.83 | GABBR2 (0.51) | GABBR2GABBR1LMNACYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6433174-B1 | Process for producing novel naphthyridine derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1142892-A1 | PROCESSES FOR THE PREPARATION OF NOVEL NAPHTHYRIDINE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2001-10-10 | — | — | EP | disclosed |
| US-5686609-A | Aromatic amine compounds, Their method of preparation and pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-11-11 | — | — | US | disclosed |
| US-5618938-A | Process for preparing stereo isomers of neurokinin receptor antagonists | SANOFI (FR) | 1997-04-08 | — | — | US | disclosed |
| US-5317020-A | Neurokinin receiver antagonist as antiinflammatory agents | SANOFI (FR) | 1994-05-31 | — | — | US | disclosed |