Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6571543 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL7804283 | 0.99 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL6574920 | 0.99 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7629724 | 0.92 | KMT2A (0.50) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7635997 | 0.92 | KMT2A (0.50) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL7798510 | 0.91 | KMT2A (0.51) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6942728 | 0.90 | GAA (0.42) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6943709 | 0.90 | GAA (0.42) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL6943626 | 0.89 | GAA (0.43) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL6944278 | 0.89 | GAA (0.43) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455737-B1 | CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS | L'OREAL S.A. (FR) | 2002-09-24 | — | — | US | claimed |
| US-6455737-B1 | CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS | L'OREAL S.A. (FR) | 2002-09-24 | — | — | US | disclosed |