SCHEMBL7635136

SCHEMBL7635136

O=C(O)c1cc2nccnc2cc1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 2/20 0.46
FGFR1 P11362 1/20 0.46
SRC P12931 1/20 0.46
CA1 P00915 3/20 0.43
CA2 P00918 3/20 0.43
ALDH1A1 P00352 3/20 0.43
CA12 O43570 2/20 0.43
CA7 P43166 2/20 0.43
CA9 Q16790 2/20 0.43
CA14 Q9ULX7 2/20 0.43
PTGS2 P35354 2/20 0.43
ALOX5 P09917 1/20 0.43
TSHR P16473 1/20 0.43
CTNNB1 P35222 1/20 0.42
PTPN1 P18031 3/20 0.41
KDM4E B2RXH2 2/20 0.41
CYP3A4 P08684 2/20 0.41
MAPT P10636 2/20 0.41
MEN1 O00255 2/20 0.41
KDR P35968 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28613073 0.86 KDM4E (0.43) MCL1ALDH1A1TSHRKDM4ECYP3A4
SCHEMBL28336465 0.77 MCL1 (0.66) MCL1ALDH1A1TSHRKDM4ECYP3A4
SCHEMBL2201880 0.77 MCL1 (0.66) MCL1FGFR1SRCALDH1A1TSHR
SCHEMBL27665821 0.77 TSHR (0.41) MCL1ALDH1A1TSHRKDM4ECYP3A4
SCHEMBL21816325 0.77 KDM4E (0.50) MCL1ALDH1A1TSHRKDM4ECYP3A4
SCHEMBL21818543 0.77 GABRP (0.48) ALDH1A1KDM4ECYP3A4MAPTMEN1
SCHEMBL9879445 0.75 EGFR (0.39) FGFR1SRCALDH1A1MAPTMEN1
SCHEMBL163610 0.75 CA1 (0.59) MCL1CA1CA2ALDH1A1CA12
SCHEMBL22206251 0.73 CA1 (0.56) MCL1CA1CA2ALDH1A1CA12
SCHEMBL460201 0.73 CA1 (0.56) MCL1CA1CA2ALDH1A1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022125736-A1 A TAUTOMERIC LIGAND ENABLES BIOMIMETIC C-H HYDROXYLATION WITH MOLECULAR OXYGEN THE SCRIPPS RESEARCH INSTITUTE (US) 2022-06-16 WO disclosed
EP-0891365-B1 BENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSES UNIV CALIFORNIA (US) 2002-10-16 EP disclosed
US-5962447-A PSYCHOLOGICAL DISORDERS, COGNITION ACTIVATORS, SCHIZOPHRENIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-10-05 US disclosed
EP-0891365-A1 BENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-01-20 EP disclosed
US-5736543-A COGNITION ACTIVATORS/NOOTROPIC AGENTS WHICH STIMULATE A-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONATE (AMPA) RECEPTORS IN BRAIN THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-04-07 US disclosed
WO-1997036907-A9 BENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSE 1997-12-04 WO disclosed
WO-1997036907-A1 BENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-10-09 WO disclosed