Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17691084 | 0.82 | GPR4 (0.34) | GPR4KCNH2 | |
| SCHEMBL1754879 | 0.81 | CYP3A4 (0.35) | GPR4KCNH2 | |
| SCHEMBL979256 | 0.81 | CYP3A4 (0.35) | GPR4KCNH2 | |
| Hydrochloric Acid SCHEMBL2898888 | 0.79 | CYP3A4 (0.34) | GPR4KCNH2 | |
| SCHEMBL9283864 | 0.78 | GPR4 (0.36) | GPR4KCNH2 | |
| SCHEMBL5337457 | 0.77 | JAK2 (0.34) | — | |
| SCHEMBL8486724 | 0.74 | — | — | |
| SCHEMBL6285083 | 0.74 | — | — | |
| SCHEMBL25954913 | 0.74 | — | — | |
| SCHEMBL92375 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458935-B1 | LABEL FPTASE IN ASSAYS, WHETHER CELL-BASED, TISSUE-BASED OR IN WHOLE ANIMAL. THE TRACERS CAN ALSO BE USED IN COMPETITIVE BINDING ASSAYS TO OBTAIN INFORMATION ON THE INTERACTION OF UNLABELED FTIS WITH FPTASE. | MERCK & CO., INC. | 2002-10-01 | — | — | US | disclosed |
| WO-2000078363-A1 | RADIOLABELED FARNESYL-PROTEIN TRANSFERASE INHIBITORS | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |
| US-6060038-A | Radiolabeled farnesyl-protein transferase inhibitors | MERCK & CO., INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0981728-A2 | RADIOLABELED FARNESYL-PROTEIN TRANSFERASE INHIBITORS | Merck & Co., Inc. (US) | 2000-03-01 | — | — | EP | disclosed |
| WO-1999000654-A2 | RADIOLABELED FARNESYL-PROTEIN TRANSFERASE INHIBITORS | MERCK & CO., INC. (US) | 1999-01-07 | — | — | WO | disclosed |