Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30025111 | 0.87 | TRPV1 (0.58) | MTNR1AMTNR1BTRPV1MEN1KMT2A | |
| SCHEMBL23535377 | 0.87 | TRPV1 (0.58) | MTNR1AMTNR1BTRPV1MEN1KMT2A | |
| SCHEMBL22980309 | 0.85 | MTNR1A (0.49) | MTNR1AMTNR1BTRPV1ALDH1A1POLB | |
| SCHEMBL8258560 | 0.78 | MTNR1A (0.52) | MTNR1AMTNR1BTRPV1MEN1KMT2A | |
| SCHEMBL21358996 | 0.78 | MPO (0.50) | MTNR1AMTNR1BALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8858530 | 0.77 | MTNR1A (0.67) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL7637774 | 0.76 | CNR1 (0.59) | MTNR1AMTNR1BALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL18793840 | 0.76 | MTNR1A (0.52) | MTNR1AMTNR1BALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL13500033 | 0.76 | MTNR1A (0.49) | MTNR1AMTNR1BTRPV1ALDH1A1POLB | |
| SCHEMBL5941728 | 0.76 | TRPV1 (0.58) | MTNR1AMTNR1BTRPV1CNR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465485-B1 | SUCH AS 7-CYANO-2-(2-(1-(4-(2-INDOLYL)CARBOXAMIDO)CYCLO-HEXYL)ETHYL)-1,2,3,4 -TETRAHYDROISOQUINOLINE; ANTIPSYCHOTIC AGENTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-10-15 | — | — | US | disclosed |