Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.34 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6113076 | 0.94 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTKMT2ATDP1CES2 | |
| SCHEMBL386768 | 0.88 | CES2 (0.50) | SMN1; SMN2HTTKMT2ATDP1CES2 | |
| SCHEMBL776566 | 0.86 | CES2 (0.55) | SMN1; SMN2HTTKMT2ATDP1CES2 | |
| SCHEMBL27553353 | 0.86 | CES2 (0.55) | SMN1; SMN2HTTKMT2ATDP1CES2 | |
| SCHEMBL248821 | 0.86 | CES2 (0.55) | SMN1; SMN2HTTKMT2ATDP1CES2 | |
| SCHEMBL6939791 | 0.86 | CES2 (0.55) | SMN1; SMN2HTTKMT2ATDP1CES2 | |
| SCHEMBL11862575 | 0.86 | CES2 (0.55) | SMN1; SMN2HTTKMT2ATDP1CES2 | |
| SCHEMBL105221 | 0.85 | KMT2A (0.40) | SMN1; SMN2HTTKMT2ATDP1CES2 | |
| SCHEMBL7910612 | 0.80 | ACE (0.44) | SMN1; SMN2HTTKMT2ATDP1CES2 | |
| SCHEMBL1863893 | 0.80 | ACE (0.44) | SMN1; SMN2HTTKMT2ATDP1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230294-A1 | STORAGE-STABLE PREPREGS ON THE BASIS OF DUROPLASTIC, OLEOCHEMICAL MATRICES | Cognis Deutschland GmbH & Co. KG (DE) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032755-A1 | STORAGE-STABLE PREPREGS ON THE BASIS OF DUROPLASTIC, OLEOCHEMICAL MATRICES | COGNIS DEUTSCHLAND GMBH & CO. KG (DE) | 2001-05-10 | — | — | WO | disclosed |