Butopyronoxyl

Butopyronoxyl

SCHEMBL7635420

CCCCOC(=O)C1=CC(=O)CC(C)(C)O1.c1ccc(COCc2ccccc2)cc1

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.49
ALDH1A1 P00352 4/20 0.49
MAPK1 P28482 3/20 0.49
TDP1 Q9NUW8 2/20 0.49
L3MBTL1 Q9Y468 2/20 0.49
CYP3A4 P08684 2/20 0.49
CTSS P25774 1/20 0.42
MAOB P27338 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
TP53 P04637 1/20 0.38
HSD17B10 Q99714 1/20 0.38
PTPN1 P18031 1/20 0.37
LMNA P02545 2/20 0.37
CYP1A2 P05177 2/20 0.37
CYP2C19 P33261 2/20 0.37
ESR1 P03372 1/20 0.37
CYP2D6 P10635 1/20 0.37
NR1H2 P55055 1/20 0.37
RNASEL Q05823 1/20 0.37
ADRA1D P25100 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butopyronoxyl SCHEMBL121985 0.88 TSHR (0.42) TSHRALDH1A1MAPK1TDP1L3MBTL1
Butopyronoxyl SCHEMBL2374236 0.86 TSHR (0.39) TSHRALDH1A1MAPK1TDP1L3MBTL1
Butopyronoxyl SCHEMBL8952222 0.85 TSHR (0.40) TSHRALDH1A1MAPK1TDP1L3MBTL1
Butopyronoxyl SCHEMBL9751913 0.75 TDP2 (0.36) TSHRALDH1A1MAPK1TDP1L3MBTL1
SCHEMBL9233896 0.72 TSHR (0.65) TSHRALDH1A1MAPK1TDP1L3MBTL1
SCHEMBL11304697 0.71 HCAR2 (0.60) TSHRALDH1A1MAPK1TDP1L3MBTL1
SCHEMBL1665160 0.68 TSHR (0.65) TSHRALDH1A1MAPK1TDP1L3MBTL1
SCHEMBL49678 0.67 TSHR (1.00) TSHRALDH1A1MAPK1TDP1L3MBTL1
SCHEMBL11416620 0.67 TSHR (0.78) TSHRALDH1A1MAPK1TDP1L3MBTL1
Dibutyl Phthalate SCHEMBL10408632 0.67 TSHR (1.00) TSHRALDH1A1MAPK1TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6380400-B1 DIMETHYLTHIOCARBAMIC ACID ESTER; VIRICIDES FEDIJ VICTOR (US) 2002-04-30 US disclosed
WO-2000015625-A2 METHODS OF MAKING DIHYDROPYRONE HIV PROTEASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2000-03-23 WO disclosed