SCHEMBL7635425

SCHEMBL7635425

CC1=Cc2c(ccc3c2ccc2ccccc23)C1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 3/20 0.50
ALDH1A1 P00352 6/20 0.43
HSD17B10 Q99714 4/20 0.43
TSHR P16473 3/20 0.43
CYP2A6 P11509 3/20 0.43
TDP1 Q9NUW8 1/20 0.43
HIF1A Q16665 2/20 0.39
HPGD P15428 2/20 0.39
CYP3A4 P08684 2/20 0.39
MAPK1 P28482 2/20 0.39
CASP1 P29466 1/20 0.39
RAB9A P51151 1/20 0.39
CASP7 P55210 1/20 0.39
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CYP1A2 P05177 4/20 0.38
PAX8 Q06710 1/20 0.38
KDM4E B2RXH2 2/20 0.38
CYP1B1 Q16678 2/20 0.38
MAPT P10636 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29481537 0.91 KDM4E (0.43) HPRT1ALDH1A1HSD17B10TSHRCYP2A6
SCHEMBL1822675 0.91 KDM4E (0.43) HPRT1ALDH1A1HSD17B10TSHRCYP2A6
Lithium SCHEMBL29773580 0.89 KDM4E (0.42) HPRT1ALDH1A1HSD17B10TSHRCYP2A6
SCHEMBL7651334 0.83 HPRT1 (0.44) HPRT1ALDH1A1HSD17B10TSHRCYP2A6
SCHEMBL30565795 0.81 HPRT1 (0.48) HPRT1ALDH1A1HSD17B10TSHRCYP2A6
SCHEMBL7637543 0.78 HPRT1 (0.45) HPRT1ALDH1A1HSD17B10TSHRCYP2A6
SCHEMBL7943148 0.78 CYP1A2 (0.50) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL6433447 0.78 HPRT1 (0.41) HPRT1ALDH1A1HSD17B10TSHRCYP2A6
SCHEMBL28249264 0.78 ALDH1A1 (0.39) HPRT1ALDH1A1HSD17B10TSHRCYP2A6
SCHEMBL4318452 0.75 CYP1A2 (0.44) ALDH1A1HSD17B10CYP2A6TDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0991674-B1 CYCLOPENTA[I]PHENANTHRENE METAL COMPLEX CATALYST SYSTEMS BASF AG (DE) 2002-04-03 EP disclosed
US-6284851-B1 Cyclopenta[I] phenanthrene-metal complex catalyst systems BASF AKTIENGESELLSCHAFT (DE) 2001-09-04 US disclosed