Terofenamate

Terofenamate

SCHEMBL7636015

CCOCOC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl.N.N

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METTL3 Q86U44 2/20 0.83
PTGS2 P35354 14/20 0.69
MEN1 O00255 2/20 0.61
MAPK1 P28482 2/20 0.61
KMT2A Q03164 2/20 0.61
AKR1B10 O60218 1/20 0.61
ABCB11 O95342 1/20 0.61
TTR P02766 1/20 0.61
ADORA3 P0DMS8 1/20 0.61
CHRM1 P11229 1/20 0.61
FABP2 P12104 1/20 0.61
RXRA P19793 1/20 0.61
TBXA2R P21731 1/20 0.61
NR4A1 P22736 1/20 0.61
PTGS1 P23219 1/20 0.61
PDE4A P27815 1/20 0.61
AKR1C3 P42330 1/20 0.61
NR4A2 P43354 1/20 0.61
AKR1C2 P52895 1/20 0.61
AKR1C1 Q04828 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Terofenamate SCHEMBL1206761 1.00 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL26088 0.99 METTL3 (0.84) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL29483481 0.99 METTL3 (0.84) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL6851974 0.98 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL15537603 0.98 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL8814628 0.98 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL1671593 0.98 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL15538328 0.98 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL22612217 0.98 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL49245 0.98 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2524934-A2 Thermoplastic polyurethane urea with biocidal properties and methods for producing same GT Elektrotechnische Produkte GmbH (DE) 2012-11-21 EP claimed
CN-106916295-B Copolyamide, moulding material comprising copolyamide and moulded articles produced therefrom EMS专利股份公司 2020-04-03 CN disclosed
US-10144805-B2 Copolyamides, moulding compounds comprising these and moulded articles produced therefrom EMS-PATENT AG (CH) 2018-12-04 US disclosed
CN-106916295-A Copolyamide, the moulding material comprising copolyamide and moulding article prepared therefrom EMS专利股份公司 2017-07-04 CN disclosed
US-20170107326-A1 COPOLYAMIDES, MOULDING COMPOUNDS COMPRISING THESE AND MOULDED ARTICLES PRODUCED THEREFROM EMS-PATENT AG (CH) 2017-04-20 US disclosed
EP-2524934-A2 Thermoplastic polyurethane urea with biocidal properties and methods for producing same GT Elektrotechnische Produkte GmbH (DE) 2012-11-21 EP disclosed
EP-0745085-B1 TEXAPHYRIN METAL COMPLEXES HAVING IMPROVED FUNCTIONALIZATION UNIV TEXAS (US) 2002-05-22 EP disclosed
US-5756726-A PHOTOSENSITIZERS PHARMACYCLICS, INC. (US) 1998-05-26 US disclosed
US-5601802-A ADMINISTERING A TEXAPHYRIN PHARMACYCLICS, INC. (US) 1997-02-11 US disclosed
US-5591422-A SENSITIZERS FOR RADIATION THERAPY PHARMACYCLICS, INC. (US) 1997-01-07 US disclosed
EP-0745085-A1 TEXAPHYRIN METAL COMPLEXES HAVING IMPROVED FUNCTIONALIZATION BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1996-12-04 EP disclosed
WO-1995021845-A1 TEXAPHYRIN METAL COMPLEXES HAVING IMPROVED FUNCTIONALIZATION BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1995-08-17 WO disclosed