Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 20/20 | 0.67 |
| ▸ | RARG | P13631 | 20/20 | 0.67 |
| ▸ | RARA | P10276 | 16/20 | 0.67 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.67 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737254 | 0.90 | RARB (0.67) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9003132 | 0.88 | RARB (0.64) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7688234 | 0.85 | RARB (0.47) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7688235 | 0.85 | RARB (0.47) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7636118 | 0.83 | RARB (0.49) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8671861 | 0.83 | RARB (0.58) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8772593 | 0.82 | RARB (0.45) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8850861 | 0.82 | RARB (0.57) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8668169 | 0.81 | RARB (0.56) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL29353973 | 0.81 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355806-B1 | REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION, AGENTS FOR TREATING SKIN-RELATED DISEASES | ALLERGEN SALES, INC. | 2002-03-12 | — | — | US | disclosed |
| US-5998471-A | SKIN DISORDERS; ANTIINFLAMMATORY AGENTS | ALLERGAN SALES, INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5808083-A | Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| US-5723620-A | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity | ALLERGAN (US) | 1998-03-03 | — | — | US | disclosed |
| US-5654469-A | FOR TREATMENT OF SKIN DISORDERS | ALLERGAN (US) | 1997-08-05 | — | — | US | disclosed |
| US-5648514-A | Substituted acetylenes having retinoid-like biological activity | ALLERGAN (US) | 1997-07-15 | — | — | US | disclosed |
| US-5543534-A | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity | ALLERGAN | 1996-08-06 | — | — | US | disclosed |
| WO-1996020930-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-07-11 | — | — | WO | disclosed |