Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 10/20 | 0.47 |
| ▸ | RARG | P13631 | 8/20 | 0.47 |
| ▸ | RARA | P10276 | 7/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 15/20 | 0.47 |
| ▸ | RXRB | P28702 | 12/20 | 0.47 |
| ▸ | RXRG | P48443 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7688234 | 1.00 | RARB (0.47) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7637331 | 0.85 | RARB (0.67) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6292739 | 0.83 | RAB9A (0.49) | RARBRARGRARAMEN1ESR1 | |
| SCHEMBL6292740 | 0.83 | RAB9A (0.49) | RARBRARGRARAMEN1ESR1 | |
| SCHEMBL6297186 | 0.81 | RXRA (0.42) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6297184 | 0.81 | RXRA (0.42) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8551591 | 0.81 | RXRA (0.66) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8972592 | 0.81 | RXRA (0.66) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8646858 | 0.79 | RXRA (0.41) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6294342 | 0.78 | RARA (0.69) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465663-B2 | ETHYL (E)-4-(2-(5,6-DIHYDRO-5,5-DIMETHYL-NAPHTHALEN-8(7H)-ONE-2 -YL)ETHENYL)BENZOATE AND ETHYL (E)-4-(2-(5,6-DIHYDRO-5,5-DIMETHYL-8-(PHENYLTHIO)-NAPHTHALENYL)ETHENYL) BENZOATE | ALLERGAN, INC. | 2002-10-15 | — | — | US | disclosed |
| EP-0915825-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 1999-05-19 | — | — | EP | disclosed |
| US-5723666-A | USEFUL AS REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION | ALLERGAN (US) | 1998-03-03 | — | — | US | disclosed |
| WO-1997048672-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1997-12-24 | — | — | WO | disclosed |