Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238878 | 0.90 | KDM4E (0.43) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7238876 | 0.90 | KDM4E (0.43) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7236548 | 0.89 | KDM4E (0.42) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7236552 | 0.89 | KDM4E (0.42) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7237785 | 0.86 | KDM4E (0.45) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7237781 | 0.86 | KDM4E (0.45) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7242556 | 0.84 | KDM4E (0.46) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7242559 | 0.84 | KDM4E (0.46) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7236509 | 0.82 | GLO1 (0.52) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7236503 | 0.82 | GLO1 (0.52) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020193599-A1 | Dihydropyridines and new uses thereof | SYNAPTIC PHARMACEUTICAL CORPORATION | 2002-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193599-A1 | Dihydropyridines and new uses thereof | BPHL, BCKDK, DHCR7 | MAPT 3869/4885KDM4E 2785/4885SMN1; SMN2 3900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.