Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | PGR | P06401 | 2/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30173685 | 0.93 | HPGD (0.64) | HPGDLMNAMAPK1CYP1A2PGR | |
| SCHEMBL989072 | 0.93 | HPGD (0.64) | HPGDLMNAMAPK1CYP1A2PGR | |
| 1,1-Dichloroethene SCHEMBL9290894 | 0.88 | HPGD (0.58) | HPGDLMNAMAPK1CYP1A2PGR | |
| SCHEMBL9290981 | 0.86 | HPGD (0.53) | HPGDLMNAMAPK1CYP1A2PGR | |
| SCHEMBL29069518 | 0.84 | HPGD (0.56) | HPGDLMNAMAPK1CYP1A2PGR | |
| SCHEMBL28847034 | 0.84 | HPGD (0.50) | HPGDLMNAMAPK1CYP1A2PGR | |
| SCHEMBL28429896 | 0.83 | LMNA (0.61) | HPGDLMNAMAPK1CYP1A2PGR | |
| SCHEMBL988408 | 0.82 | LMNA (0.49) | HPGDLMNAMAPK1CYP1A2PGR | |
| SCHEMBL4190225 | 0.82 | HPGD (0.54) | HPGDLMNAMAPK1CYP1A2PGR | |
| SCHEMBL17352435 | 0.82 | MAPK1 (0.59) | HPGDLMNAMAPK1CYP1A2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465588-B1 | PARTICULARLY SUITABLE FOR FOLDABLE INTRAOCULAR LENS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-10-15 | — | — | US | disclosed |
| EP-1026182-A1 | FOUR COMPONENT COPOLYMER AND THE OCULAR LENS MADE THEREOF | SANTEN PHARMACEUTICAL CO., LTD (JP) | 2000-08-09 | — | — | EP | disclosed |