SCHEMBL7640569

SCHEMBL7640569

C=Cc1ccc2c(c1)CC=C2

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
TP53 P04637 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
MAPT P10636 1/20 0.32
PKM P14618 1/20 0.32
TRPA1 O75762 1/20 0.32
SRD5A1 P18405 1/20 0.31
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7641543 0.84 ALDH1A1 (0.39) ALDH1A1TP53TDP1MAPTPKM
SCHEMBL28029104 0.81 ALDH1A1 (0.36) ALDH1A1TP53TDP1MAPTPKM
SCHEMBL2856444 0.80 ALDH1A1 (0.38) ALDH1A1TDP1MAPTTSHR
SCHEMBL27108550 0.73 ALDH1A1 (0.36) ALDH1A1TP53TDP1MAPTPKM
Indene SCHEMBL29813684 0.73 ALDH1A1 (0.52) ALDH1A1TP53TDP1TSHR
Indene SCHEMBL200671 0.73 ALDH1A1 (0.52) ALDH1A1TP53TDP1TSHR
Indene SCHEMBL9444068 0.73 ALDH1A1 (0.52) ALDH1A1TP53TDP1TSHR
Indene SCHEMBL28314049 0.73 CYP2C19 (0.43) ALDH1A1TP53TDP1MAPTTSHR
Indene SCHEMBL4021084 0.72 CYP1A2 (0.39) ALDH1A1TDP1TSHR
SCHEMBL4478309 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3720597-B1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES STICHTING TECHNISCHE WETENSCHAPPEN (NL) 2023-11-29 EP claimed
US-11612877-B2 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-03-28 US claimed
US-20200368721-A1 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2020-11-26 US claimed
EP-3720597-A1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF Stichting voor de Technische Wetenschappen (NL) 2020-10-14 EP claimed
WO-2019110557-A1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2019-06-13 WO claimed
US-12318756-B2 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof UNIVERSITEIT UTRECHT HOLDING B.V. (NL) 2025-06-03 US disclosed
EP-3720597-B1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES STICHTING TECHNISCHE WETENSCHAPPEN (NL) 2023-11-29 EP disclosed
US-20230201799-A1 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-06-29 US disclosed
US-11612877-B2 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2023-03-28 US disclosed
US-20200368721-A1 Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2020-11-26 US disclosed
EP-3720597-A1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF Stichting voor de Technische Wetenschappen (NL) 2020-10-14 EP disclosed
WO-2019110557-A1 MACROMOLECULAR COMPOSITIONS COMPRISING INDENE-DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) 2019-06-13 WO disclosed
US-6372930-B1 POLYMERIC LIGAND HAVING UNITS CONTAINING AT LEAST ONE BRIDGED CYCLOPENTADIENYL-TYPE GROUP INCLUDING AT LEAST ONE FLUORENYL-TYPE GROUP PHILLIPS PETROLEUM COMPANY 2002-04-16 US disclosed
US-6124414-A POLYMERIC METALLOCENE CATALYST WHICH IS PREPARED BY POLYMERIZING A 2-VINYLFLUORENE OR BY REACTING FLUORENE COMPOUND WITH CHLOROMETHYLMETHYLETHER, REACTING THE POLYMER WITH ALKALI METAL AND THEN WITH TRANSITIONAL METAL COMPOUND PHILLIPS PETROLEUM COMPANY (US) 2000-09-26 US disclosed
US-6057410-A COMPLEXING FOR POLYMERIZATION CATALYSTS A PENTADIENYL LIGAND AND POLYMERIZATION WITH INITIATORS PHILLIPS PETROLEUM COMPANY (US) 2000-05-02 US disclosed
US-6040402-A PRODUCT OF REACTING A FLUORENYL-CONTAINING POLYMER WITH AN ALKALI METAL COMPOUND; AND REACTING THE PRODUCT OF STEP WITH A TRANSITION METAL-CONTAINING COMPOUND. PHILLIPS PETROLEUM COMPANY (US) 2000-03-21 US disclosed
US-5770755-A REACTION OF TRANSITION METAL COMPOUND WITH POLYMER CONTAINING CYCLOPENTADIENE, INDENE, OR FLUORENE GROUPS PHILLIPS PETROLEUM COMPANY (US) 1998-06-23 US disclosed