SCHEMBL2856444

SCHEMBL2856444

O=Cc1ccc2c(c1)CC=C2

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.38
MEN1 O00255 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
KMT2A Q03164 1/20 0.38
KDM4E B2RXH2 1/20 0.38
PTGS2 P35354 1/20 0.38
RAB9A P51151 1/20 0.38
HSD17B10 Q99714 2/20 0.37
TDP1 Q9NUW8 1/20 0.37
CYP2A6 P11509 5/20 0.36
TSHR P16473 1/20 0.34
ALDH1A3 P47895 2/20 0.33
UNG P13051 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1803456 0.84 ALDH1A1 (0.38) ALDH1A1MEN1GAAMAPTHPGD
SCHEMBL29561757 0.84 ALDH1A1 (0.38) ALDH1A1MEN1GAAMAPTHPGD
SCHEMBL27761248 0.82 ALDH1A1 (0.36) ALDH1A1MEN1GAAMAPTHPGD
SCHEMBL4405513 0.81 ALDH1A1 (0.39) ALDH1A1MEN1GAAMAPTHPGD
SCHEMBL4402546 0.80 CYP2A6 (0.39) ALDH1A1MEN1GAAMAPTHPGD
SCHEMBL4408087 0.80 CYP2A6 (0.39) ALDH1A1MEN1GAAMAPTHPGD
SCHEMBL7640569 0.80 ALDH1A1 (0.39) ALDH1A1MAPTTDP1TSHR
SCHEMBL29521419 0.78 ALDH1A1 (0.44) ALDH1A1MEN1GAAMAPTHPGD
SCHEMBL4402532 0.77 ALDH1A1 (0.41) ALDH1A1MEN1GAAMAPTHPGD
SCHEMBL275981 0.74 TUBB4A (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11952493-B2 Moisture-curing polyurethane composition containing oxazolidine SIKA TECHNOLOGY AG (CH) 2024-04-09 US disclosed
CN-113272299-B Moisture-curable polyurethane compositions comprising oxazolidines SIKA技术股份公司 2023-07-07 CN disclosed
EP-3898619-B1 MOISTURE-CURABLE POLYURETHANE COMPOSITION CONTAINING OXAZOLIDINE SIKA TECH AG (CH) 2023-02-08 EP disclosed
CN-110099951-B Surface treated fillers for polyester films OMYA国际股份公司 2022-04-01 CN disclosed
US-20220025176-A1 MOISTURE-CURING POLYURETHANE COMPOSITION CONTAINING OXAZOLIDINE SIKA TECHNOLOGY AG (CH) 2022-01-27 US disclosed
CN-113272299-A Moisture-curing polyurethane composition comprising oxazolidine SIKA技术股份公司 2021-08-17 CN disclosed
CN-112105654-A Curable resin mixture, curable resin composition, and cured product thereof 日本化药株式会社 2020-12-18 CN disclosed
WO-2020031935-A1 CURABLE RESIN MIXTURE, CURABLE RESIN COMPOSITION, AND CURED PRODUCT 日本化薬株式会社 2020-02-13 WO disclosed
US-20180222917-A1 COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA COLD SPRING HARBOR LABORATORY 2018-08-09 US disclosed
US-20170360801-A1 BROMODOMAIN INHIBITOR AS ADJUVANT IN CANCER IMMUNOTHERAPY H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. 2017-12-21 US disclosed
EP-2188242-A2 CYCLOHEXENE DERIVATIVES AND THEIR USE AS ODORANTS Givaudan SA (CH) 2010-05-26 EP disclosed
US-7700789-B2 Heterogeneous catalyst and process for producing oxirane compound with the catalyst NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-04-20 US disclosed
EP-1632291-B1 HETEROGENEOUS CATALYST AND PROCESS FOR PRODUCING OXIRANE COMPOUND WITH THE CATALYST NISSAN CHEMICAL IND LTD (JP) 2009-12-16 EP disclosed
EP-2106855-A1 Heterogeneous catalyst and process for producing oxirane compound with the catalyst Nissan Chemical Industries, Ltd. (JP) 2009-10-07 EP disclosed
US-20090082583-A1 Heterogeneous catalyst and process for producing oxirane compound with the catalyst NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-03-26 US disclosed
WO-2009021342-A2 CYCLOHEXENE DERIVATIVES AND THEIR USE AS ODORANTS GIVAUDAN SA (CH) 2009-02-19 WO disclosed
US-20070093667-A1 Heterogeneous catalyst and process for producing oxirane compound with the catalyst NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2007-04-26 US disclosed
EP-1632291-A1 HETEROGENEOUS CATALYST AND PROCESS FOR PRODUCING OXIRANE COMPOUND WITH THE CATALYST Nissan Chemical Industries, Ltd. (JP) 2006-03-08 EP disclosed
US-20050282730-A1 Thrombopoetin receptor activator and process for producing the same NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2005-12-22 US disclosed
EP-1552828-A1 THROMBOPOETIN RECEPTOR ACTIVATOR AND PROCESS FOR PRODUCING THE SAME Nissan Chemical Industries, Ltd. (JP) 2005-07-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070093667-A1 Heterogeneous catalyst and process for producing oxirane compound with the catalyst OXGR1, OXER1, OGFOD1 ALDH1A1 800/4885MEN1 3099/4885GAA 1623/4885
US-20090082583-A1 Heterogeneous catalyst and process for producing oxirane compound with the catalyst OXGR1, OGFOD1, OGDH ALDH1A1 614/4885MEN1 3345/4885GAA 1608/4885
US-20050282730-A1 Thrombopoetin receptor activator and process for producing the same PDGFRA, PTAFR, TBXA2R ALDH1A1 2034/4885MEN1 2530/4885GAA 4869/4885
US-20170360801-A1 BROMODOMAIN INHIBITOR AS ADJUVANT IN CANCER IMMUNOTHERAPY BRDT, BRD4, BRD1 ALDH1A1 2424/4885MEN1 4108/4885GAA 3709/4885
US-20180222917-A1 COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA MCL1, ABL1, FLT3 ALDH1A1 1723/4885MEN1 2413/4885GAA 1077/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.