Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 7/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL178631 | 0.81 | HTR2A (0.40) | HTR2ASLC6A4KCNH2CYP2D6 | |
| SCHEMBL26948996 | 0.81 | CES2 (0.41) | CES2CES1HTR2ASLC6A4KCNH2 | |
| SCHEMBL2668988 | 0.81 | CES2 (0.41) | CES2CES1HTR2ASLC6A4KCNH2 | |
| SCHEMBL17553266 | 0.77 | CES2 (0.41) | CES2CES1 | |
| SCHEMBL12049608 | 0.77 | CES2 (0.44) | CES2CES1NPC1ADRA1A | |
| SCHEMBL178490 | 0.74 | SLC6A4 (0.50) | HTR2ASLC6A4KCNH2CYP2D6 | |
| SCHEMBL178501 | 0.74 | SLC6A4 (0.39) | HTR2ASLC6A4KCNH2CYP2D6 | |
| SCHEMBL9070739 | 0.74 | SLC6A4 (0.50) | HTR2ASLC6A4KCNH2CYP2D6 | |
| SCHEMBL24989671 | 0.73 | CES2 (0.41) | CES2CES1 | |
| SCHEMBL16956342 | 0.73 | CES2 (0.41) | CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883824-B2 | 3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2014-11-11 | — | — | US | disclosed |
| EP-2431362-A1 | 3-(4-AMINOPHENYL)-2-FURANCARBOXYLIC ACID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131669-A1 | 3-(4-AMINOPHENYL)-2-FURANCARBOXYLIC ACID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | 大日本住友製薬株式会社 (JP) | 2010-11-18 | — | — | WO | disclosed |