Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 4/20 | 0.48 |
| ▸ | TNF | P01375 | 7/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | DUT | P33316 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7636901 | 0.79 | MAPK14 (0.60) | MAPK14 | |
| SCHEMBL30910238 | 0.76 | GPR84 (0.47) | KAT2BALDH1A1KDM4EGAATSHR | |
| SCHEMBL5005631 | 0.76 | ACACB (0.44) | ALDH1A1GAATSHRDRD2DRD3 | |
| SCHEMBL1998981 | 0.73 | DRD2 (0.41) | TNFDRD2DRD3MAPK14 | |
| SCHEMBL2881295 | 0.72 | CYP1A2 (0.54) | ALDH1A1KDM4E | |
| SCHEMBL31584793 | 0.71 | TNF (0.47) | KAT2BTNFALDH1A1TSHRDUT | |
| SCHEMBL22610155 | 0.71 | CDK4 (0.60) | TNFALDH1A1TSHR | |
| SCHEMBL1038378 | 0.70 | GRM2 (0.41) | ALDH1A1TSHR | |
| SCHEMBL18913971 | 0.70 | GSK3A (0.46) | TNFALDH1A1KDM4ETSHR | |
| SCHEMBL24110048 | 0.70 | TNF (0.39) | KAT2BTNFALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465495-B1 | INHIBITING DISEASE STATES ASSOCIATED WITH PROTEIN PROTEIN INTERACTION MEDIATED BY A SH2 OR SH3 DOMAIN OR A TYROSINE PHOSPHATASE SUCH AS ALLERGIES, ASTHMA, ANEMIA, AUTOIMMUNE DISEASES, CANCER, INFLAMMATORY DISEASES, OSTEOPOROSIS | OSI PHARMACEUTICALS, INC. | 2002-10-15 | — | — | US | disclosed |