SCHEMBL7641485

SCHEMBL7641485

COC(=O)CN(CCNC(c1ccccc1)(c1ccccc1)c1ccc(OC)cc1)C(=O)Cn1ccnn1

nearest known ligand 0.33

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
KIF11 P52732 4/20 0.32
KMT2A Q03164 1/20 0.32
MTNR1A P48039 1/20 0.32
MTNR1B P49286 1/20 0.32
CYP19A1 P11511 4/20 0.32
SIGMAR1 Q99720 1/20 0.31
TSPO P30536 1/20 0.31
ALOX5 P09917 1/20 0.31
F2 P00734 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
TSHR P16473 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7644928 0.94 HDAC1 (0.33) HDAC1HDAC8HDAC6KIF11KMT2A
SCHEMBL7637178 0.84 CYP19A1 (0.43) CYP19A1TSHR
SCHEMBL7641429 0.84 IDH1 (0.37) HDAC1HDAC8HDAC6KMT2ACYP19A1
SCHEMBL7637994 0.82 RNF4 (0.41) KIF11KMT2AMTNR1AMTNR1BSIGMAR1
SCHEMBL7641484 0.78 CYP19A1 (0.37) KMT2AMTNR1AMTNR1BCYP19A1
SCHEMBL7645537 0.78 CYP19A1 (0.44) CYP19A1TSHR
SCHEMBL7639802 0.77 SMN1; SMN2 (0.32) KMT2ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7639302 0.77 TK1 (0.46)
SCHEMBL6486208 0.72 RET (0.47) KMT2ASIGMAR1F2CYP1A2CYP3A4
SCHEMBL7634148 0.71 SMN1; SMN2 (0.33) KMT2ACYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6465650-B1 INTERMEDIATE STEPS IN PREPARING PEPTIDE NUCLEIC ACIDS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-10-15 US disclosed
US-6075143-A USEFUL FOR FORMING PEPTIDE NUCLEIC ACIDS OR HYBRID OF PEPTIDE NUCLEIC ACIDS AND DEOXYNUCLEIC ACID HOECHST AKTIENGESELLSCHAFT (DE) 2000-06-13 US disclosed