Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 2/20 | 0.65 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.59 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.59 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.59 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.59 |
| ▸ | LDHA | P00338 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | FBP1 | P09467 | 1/20 | 0.59 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.59 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.59 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5249503 | 0.85 | ADORA3 (0.58) | PRKACAADORA1SMN1; SMN2ADORA3ADORA2B | |
| SCHEMBL5249494 | 0.85 | ADORA3 (0.58) | PRKACAADORA1SMN1; SMN2ADORA3ADORA2B | |
| SCHEMBL10786307 | 0.84 | ADORA1 (0.72) | P2RY1ADORA1P2RY2SMN1; SMN2SRC | |
| SCHEMBL8328542 | 0.84 | ADORA1 (0.74) | P2RY1ADORA1P2RY2SMN1; SMN2SRC | |
| SCHEMBL5981804 | 0.84 | ADORA1 (0.61) | PRKACAADORA1SMN1; SMN2ADORA3ADORA2B | |
| SCHEMBL5981813 | 0.84 | ADORA1 (0.61) | PRKACAADORA1SMN1; SMN2ADORA3ADORA2B | |
| SCHEMBL8671033 | 0.82 | EHMT1 (0.74) | P2RY1ADORA1P2RY2SMN1; SMN2SRC | |
| SCHEMBL8671037 | 0.82 | EHMT1 (0.74) | P2RY1ADORA1P2RY2SMN1; SMN2SRC | |
| SCHEMBL29936475 | 0.82 | EHMT1 (0.74) | P2RY1ADORA1P2RY2SMN1; SMN2SRC | |
| SCHEMBL9231760 | 0.82 | EHMT1 (0.76) | P2RY1ADORA1P2RY2SMN1; SMN2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222309-A4 | HUMAN RNASE H AND OLIGONUCLEOTIDE COMPOSITIONS THEREOF | ISIS PHARMACEUTICALS INC (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-1222309-A1 | HUMAN RNASE H AND OLIGONUCLEOTIDE COMPOSITIONS THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001023613-A1 | HUMAN RNASE H AND OLIGONUCLEOTIDE COMPOSITIONS THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 2001-04-05 | — | — | WO | disclosed |
| WO-2000004189-A1 | MODIFIED OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 2000-01-27 | — | — | WO | disclosed |