Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9359371 | 0.80 | OPRM1 (0.51) | OPRL1OPRM1OPRK1OPRD1MBTD1 | |
| SCHEMBL12856303 | 0.78 | OPRL1 (0.50) | OPRL1OPRM1OPRK1OPRD1MBTD1 | |
| SCHEMBL6628090 | 0.78 | OPRM1 (0.43) | OPRL1OPRM1OPRK1L3MBTL3ALDH1A1 | |
| SCHEMBL121604 | 0.77 | L3MBTL3 (0.34) | OPRL1OPRM1OPRK1MBTD1L3MBTL3 | |
| SCHEMBL21047675 | 0.76 | OPRM1 (0.46) | OPRL1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL1181799 | 0.76 | OPRM1 (0.46) | OPRL1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL551401 | 0.76 | OPRM1 (0.46) | OPRL1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL7634170 | 0.76 | OPRM1 (0.46) | OPRL1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL7633925 | 0.76 | OPRM1 (0.46) | OPRL1OPRM1OPRK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3665053 | 0.75 | L3MBTL3 (0.33) | OPRL1OPRM1OPRK1MBTD1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0963987-B1 | Spiro(piperidine-4,1'-pyrrolo(3,4-c)pyrrole) | HOFFMANN LA ROCHE (CH) | 2002-08-28 | — | — | EP | disclosed |
| US-6075034-A | Spiro[piperidine-4,1'-pyrrolo [3,4-C] pyrrole]derivatives | HOFFMANN-LA ROCHE INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0963987-A2 | Spiro(piperidine-4,1'-pyrrolo(3,4-c)pyrrole) | F. HOFFMANN-LA ROCHE AG (CH) | 1999-12-15 | — | — | EP | disclosed |