Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12832039 | 0.90 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDNPC1SMN1; SMN2 | |
| SCHEMBL22602024 | 0.90 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDNPC1SMN1; SMN2 | |
| SCHEMBL11563242 | 0.90 | KMT2A (0.60) | ALDH1A1KDM4EHPGDNPC1SMN1; SMN2 | |
| SCHEMBL11561740 | 0.90 | POLB (0.60) | ALDH1A1KDM4EHPGDNPC1SMN1; SMN2 | |
| SCHEMBL11563461 | 0.89 | NOS2 (0.58) | ALDH1A1KDM4EHPGDNPC1SMN1; SMN2 | |
| SCHEMBL16001177 | 0.88 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDNPC1SMN1; SMN2 | |
| SCHEMBL13879786 | 0.88 | CXCR4 (0.54) | ALDH1A1KDM4EHPGDNPC1RAB9A | |
| SCHEMBL18772850 | 0.87 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A | |
| SCHEMBL3669945 | 0.87 | NPC1 (0.63) | ALDH1A1KDM4EHPGDNPC1RAB9A | |
| SCHEMBL11564368 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078015-B1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1 AND/OR NF-KAPPAB ACTIVITY AND USE THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2008057859-A2 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-I AND/OR NF-KAPPAB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-15 | — | — | WO | disclosed |
| EP-0000816-A1 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1979-02-21 | — | — | EP | disclosed |