Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6377969 | 1.00 | KMT2A (0.59) | KMT2AALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL7515852 | 0.90 | KMT2A (0.59) | KMT2AALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL6378072 | 0.84 | ALDH1A1 (0.51) | KMT2AALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL27417336 | 0.83 | ALDH1A1 (0.49) | KMT2AALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL6239098 | 0.82 | ALDH1A1 (0.55) | KMT2AALDH1A1KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL6952465 | 0.80 | HCAR3 (0.62) | ALDH1A1KDM4ERAB9AMAPTCASP6 | |
| SCHEMBL8324794 | 0.80 | TSHR (0.49) | CASP6POLBHCAR3 | |
| SCHEMBL6378059 | 0.79 | HCAR3 (0.57) | MAPTCASP6POLBHCAR3 | |
| SCHEMBL6378063 | 0.79 | HCAR3 (0.57) | MAPTCASP6POLBHCAR3 | |
| SCHEMBL4024705 | 0.79 | KDM4E (0.52) | KMT2AALDH1A1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225895-A4 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-1225895-A1 | FAB I INHIBITORS | SmithKline Beecham Corporation (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001026654-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-19 | — | — | WO | disclosed |