Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 7/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602632 | 0.90 | PFKFB3 (0.40) | PFKFB3FADS1PDPK1HPGDSCDK1 | |
| SCHEMBL7606688 | 0.89 | PFKFB3 (0.42) | PFKFB3FADS1PDPK1HPGDSCDK1 | |
| SCHEMBL4109902 | 0.79 | MAPT (0.44) | PFKFB3FADS1PDPK1HPGDSKDM4E | |
| SCHEMBL3408320 | 0.79 | HPGDS (0.37) | PFKFB3HPGDSKDM4ELMNAALOX15 | |
| SCHEMBL3410594 | 0.79 | NPY1R (0.40) | HPGDSKDM4ELMNAALOX15TSHR | |
| SCHEMBL3429547 | 0.78 | PFKFB3 (0.39) | PFKFB3FADS1PDPK1HPGDSCDK1 | |
| SCHEMBL3415257 | 0.78 | HPGDS (0.46) | PFKFB3FADS1PDPK1HPGDSEGFR | |
| SCHEMBL3411790 | 0.78 | NPC1 (0.42) | PFKFB3FADS1PDPK1HPGDSLMNA | |
| SCHEMBL7602597 | 0.77 | CA1 (0.49) | PFKFB3FADS1HPGDSCDK1KDM4E | |
| SCHEMBL3414984 | 0.77 | AURKA (0.41) | PFKFB3FADS1HPGDSCDK1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183380-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090227570-A1 | 2-AMINOQUINOLINES | HOFFMANN-LA ROCHE, INC. | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227570-A1 | 2-AMINOQUINOLINES | HTR5A, HTR2C, HTR2A | PFKFB3 2701/4885FADS1 2068/4885PDPK1 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.