Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.38 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.38 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.38 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.38 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.38 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.38 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.38 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.38 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13165713 | 0.94 | MAPK14 (0.40) | BDKRB1MAPK14EPHX2CTSLCTSK | |
| SCHEMBL13166110 | 0.91 | MAPK14 (0.39) | BDKRB1MAPK14EPHX2CTSLHPGD | |
| SCHEMBL10121335 | 0.90 | BDKRB1 (0.45) | BDKRB1HPGDSCN9A | |
| SCHEMBL765640 | 0.89 | SCN9A (0.38) | BDKRB1MAPK14PSMB11PSMA7PSMB1 | |
| SCHEMBL764425 | 0.89 | BDKRB1 (0.48) | BDKRB1MAPK14PSMB11PSMA7PSMB1 | |
| SCHEMBL765827 | 0.88 | BDKRB1 (0.39) | BDKRB1MAPK14PSMB11PSMA7PSMB1 | |
| SCHEMBL12238931 | 0.88 | EPHX2 (0.53) | BDKRB1MAPK14EPHX2CTSL | |
| SCHEMBL765568 | 0.87 | SCN9A (0.37) | BDKRB1MAPK14PSMB11PSMA7PSMB1 | |
| SCHEMBL13904206 | 0.86 | BDKRB1 (0.39) | BDKRB1PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL13165586 | 0.86 | BDKRB1 (0.41) | BDKRB1HPGDSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |