Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.36 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.35 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.35 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.35 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.35 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.35 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.35 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.35 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.35 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13165719 | 0.94 | SCN9A (0.36) | SCN9APLA2G7CARM1PRMT6BDKRB1 | |
| SCHEMBL765568 | 0.92 | SCN9A (0.37) | SCN9APLA2G7CARM1PRMT6BDKRB1 | |
| SCHEMBL13165722 | 0.90 | SCN9A (0.35) | SCN9APLA2G7CARM1PRMT6FFAR1 | |
| SCHEMBL764500 | 0.89 | BDKRB1 (0.43) | SCN9ABDKRB1PSMB11PSMA7PSMB1 | |
| SCHEMBL765826 | 0.89 | PSMB11 (0.36) | SCN9ACARM1PRMT6BDKRB1PSMB11 | |
| SCHEMBL764451 | 0.89 | BDKRB1 (0.35) | SCN9ACARM1PRMT6BDKRB1PSMB11 | |
| SCHEMBL12238932 | 0.87 | L3MBTL1 (0.43) | PLA2G7BDKRB1ALDH1A1 | |
| SCHEMBL764425 | 0.87 | BDKRB1 (0.48) | SCN9ACARM1PRMT6BDKRB1PSMB11 | |
| SCHEMBL13904206 | 0.87 | BDKRB1 (0.39) | SCN9ACARM1PRMT6BDKRB1PSMB11 | |
| SCHEMBL13904098 | 0.86 | CACNA1B (0.34) | SCN9ACARM1PRMT6BDKRB1PSMB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2009027450-A1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-05 | — | — | WO | disclosed |