Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 1.00 |
| ▸ | HTR2C | P28335 | 10/20 | 1.00 |
| ▸ | DRD2 | P14416 | 7/20 | 0.76 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7646413 | 0.84 | HTR2A (1.00) | HTR2AHTR2CDRD2HTR6CNR1 | |
| SCHEMBL27732955 | 0.82 | HTR2A (0.69) | HTR2AHTR2CDRD2CNR1 | |
| SCHEMBL20970934 | 0.81 | HTR6 (0.71) | HTR2AHTR2CDRD2HTR6 | |
| SCHEMBL29536604 | 0.81 | HTR6 (0.71) | HTR2AHTR2CDRD2HTR6 | |
| SCHEMBL30288465 | 0.80 | HTR2A (0.67) | HTR2AHTR2CDRD2HTR6 | |
| SCHEMBL30288461 | 0.80 | HTR2A (0.67) | HTR2AHTR2CDRD2HTR6 | |
| SCHEMBL28286983 | 0.80 | HTR2A (0.66) | HTR2AHTR2CDRD2CNR1 | |
| SCHEMBL10933049 | 0.79 | HTR2A (0.69) | HTR2AHTR2CDRD2CNR1 | |
| SCHEMBL12877452 | 0.79 | HTR2A (0.64) | HTR2AHTR2CDRD2CNR1 | |
| SCHEMBL11817240 | 0.77 | HTR2A (0.62) | HTR2AHTR2CDRD2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486153-B1 | Phenylindole derivatives as 5-HT2A receptor ligands | MERCK SHARP & DOHME LTD. | 2002-11-26 | — | — | US | disclosed |