Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LIPE | Q05469 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6044868 | 0.98 | CA12 (0.44) | CA12CA1CA2CA9SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6043366 | 0.82 | SMN1; SMN2 (0.42) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL2413232 | 0.82 | CYP2D6 (0.45) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL10509006 | 0.82 | KDM4E (0.48) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL9551386 | 0.81 | CA12 (0.47) | CA12CA1CA2CA9SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6045387 | 0.80 | GNAI3 (0.43) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL7369109 | 0.79 | CA12 (0.45) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL8054253 | 0.79 | CYP2D6 (0.46) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL10703372 | 0.79 | SMN1; SMN2 (0.46) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL3877365 | 0.79 | CA12 (0.45) | CA12CA1CA2CA9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026162-A | Cystine knot scaffold platform | 豪夫迈·罗氏有限公司 | 2018-05-11 | — | — | CN | claimed |
| CN-108026162-A | Cystine knot scaffold platform | 豪夫迈·罗氏有限公司 | 2018-05-11 | — | — | CN | disclosed |
| EP-1216242-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| US-6355637-B1 | QUINAZOLONES FOR LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001025235-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |