Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR1 | P21462 | 17/20 | 0.47 |
| ▸ | FPR2 | P25090 | 12/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12284519 | 1.00 | FPR1 (0.47) | FPR1FPR2EPHX2NFKB1NFKB2 | |
| SCHEMBL12665948 | 1.00 | FPR1 (0.47) | FPR1FPR2EPHX2NFKB1NFKB2 | |
| SCHEMBL12284238 | 0.88 | FPR1 (0.53) | FPR1FPR2EPHX2 | |
| SCHEMBL19988711 | 0.88 | FPR1 (0.61) | FPR1FPR2EPHX2 | |
| SCHEMBL764675 | 0.88 | FPR1 (0.53) | FPR1FPR2EPHX2 | |
| SCHEMBL12665952 | 0.88 | FPR1 (0.53) | FPR1FPR2EPHX2 | |
| SCHEMBL20001295 | 0.85 | FPR1 (0.66) | FPR1FPR2 | |
| SCHEMBL19988417 | 0.85 | FPR1 (0.66) | FPR1FPR2 | |
| SCHEMBL170772 | 0.84 | KDM1A (0.39) | FPR1FPR2EPHX2NFKB1NFKB2 | |
| SCHEMBL462830 | 0.84 | KDM1A (0.39) | FPR1FPR2EPHX2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1921917-B1 | FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-1819674-B1 | FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2007070434-A2 | FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-4 INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007024993-A2 | FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2006058064-A2 | FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2006-06-01 | — | — | WO | disclosed |