Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7751806 | 0.98 | IDH1 (0.47) | IDH1TLR8CHRNB2CHRNA7CHRNA4 | |
| Hydrochloric Acid SCHEMBL10754555 | 0.80 | PLAU (0.47) | CYP1A2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL3952728 | 0.79 | IDH1 (0.54) | IDH1TLR8MTNR1AMTNR1BCYP1A2 | |
| SCHEMBL30727531 | 0.79 | IDH1 (0.54) | IDH1TLR8MTNR1AMTNR1BCYP1A2 | |
| SCHEMBL29418808 | 0.79 | IDH1 (0.54) | IDH1TLR8MTNR1AMTNR1BCYP1A2 | |
| Hydrochloric Acid SCHEMBL10800502 | 0.78 | CYP1A2 (0.57) | CYP1A2BLMCHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL30520291 | 0.77 | IDH1 (0.52) | IDH1TLR8MTNR1AMTNR1BCYP1A2 | |
| Hydrochloric Acid SCHEMBL29678754 | 0.77 | IDH1 (0.52) | IDH1TLR8MTNR1AMTNR1BCYP1A2 | |
| Hydrochloric Acid SCHEMBL30520083 | 0.77 | IDH1 (0.52) | IDH1TLR8MTNR1AMTNR1BCYP1A2 | |
| SCHEMBL7919050 | 0.76 | CYP2D6 (0.59) | CYP1A2ACHEBLMCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6475247-B1 | Naphthalene cationic coupler for oxidation dyeing of keratin fiber | L'OREAL S.A. (FR) | 2002-11-05 | — | — | US | claimed |
| US-6475247-B1 | Naphthalene cationic coupler for oxidation dyeing of keratin fiber | L'OREAL S.A. (FR) | 2002-11-05 | — | — | US | disclosed |