SCHEMBL7647131

SCHEMBL7647131

COc1sc(C(N)=O)c(-c2ccccc2)c1S(N)(=O)=O

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
IKBKB O14920 10/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
BTK Q06187 1/20 0.41
NPSR1 Q6W5P4 3/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
MAPT P10636 1/20 0.38
CCNC P24863 2/20 0.38
CDK8 P49336 2/20 0.38
CDK19 Q9BWU1 2/20 0.38
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
BCAT2 O15382 1/20 0.37
LIMK1 P53667 1/20 0.37
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6909612 0.89 MAPT (0.43) ALDH1A1NPSR1L3MBTL1MAPTKMT2A
SCHEMBL7647139 0.89 ALDH1A1 (0.42) ALDH1A1IKBKBCYP1A2CYP3A4CYP2C9
SCHEMBL7646538 0.82 ALDH1A1 (0.48) ALDH1A1IKBKBCYP1A2CYP3A4CYP2C9
SCHEMBL6909619 0.81 MAPT (0.40) ALDH1A1NPSR1L3MBTL1MAPTKMT2A
SCHEMBL7643236 0.80 ALDH1A1 (0.49) ALDH1A1IKBKBCYP1A2CYP3A4CYP2C9
SCHEMBL7640473 0.80 ALDH1A1 (0.49) ALDH1A1IKBKBCYP1A2CYP3A4CYP2C9
SCHEMBL7641003 0.80 ALDH1A1 (0.46) ALDH1A1IKBKBCYP1A2CYP3A4CYP2C9
SCHEMBL6913310 0.78 ALDH1A1 (0.45) ALDH1A1IKBKBCYP1A2CYP3A4CYP2C9
SCHEMBL7643249 0.77 ALDH1A1 (0.46) ALDH1A1IKBKBCYP1A2CYP3A4CYP2C9
SCHEMBL7643303 0.77 NPSR1 (0.42) ALDH1A1IKBKBCYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6432994-B1 CARDIOVASCULAR DISORDERS, GLAUCOMA; ANTIINFLAMMATORY, WOUND HEALING, HYPOTENSIVE, ANTIASTHMATIC, AND ANTIANAPHYLACTIC AGENTS TEXAS BIOTECHNOLOGY CORPORATION 2002-08-13 US disclosed
EP-0699191-A1 SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN TEXAS BIOTECHNOLOGY CORPORATION (US) 1996-03-06 EP disclosed
WO-1994027979-A1 SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN IMMUNOPHARMACEUTICS, INC. (US) 1994-12-08 WO disclosed