Sugi Predict

Sugi Predict / Compounds / SCHEMBL6909612

SCHEMBL6909612

SCHEMBL6909612

COc1sc(C(C)=O)c(-c2ccccc2)c1S(N)(=O)=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.43
▸ KDM4E B2RXH2 3/20 0.43
▸ LMNA P02545 3/20 0.43
▸ RXFP1 Q9HBX9 3/20 0.43
▸ PKM P14618 1/20 0.43
▸ NPSR1 Q6W5P4 5/20 0.40
▸ KMT2A Q03164 4/20 0.36
▸ GAA P10253 2/20 0.36
▸ ALDH1A1 P00352 4/20 0.36
▸ HPGD P15428 2/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ RAB9A P51151 3/20 0.35
▸ PDE4A P27815 3/20 0.35
▸ PDE4B Q07343 3/20 0.35
▸ PDE4C Q08493 3/20 0.35
▸ PDE4D Q08499 3/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ GRM6 O15303 2/20 0.35
▸ NPC1 O15118 2/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7647131 0.89 ALDH1A1 (0.45) MAPTNPSR1KMT2AGAAALDH1A1
SCHEMBL6909619 0.89 MAPT (0.40) MAPTKDM4ELMNARXFP1PKM
SCHEMBL7647139 0.81 ALDH1A1 (0.42) MAPTNPSR1KMT2AGAAALDH1A1
SCHEMBL7646538 0.70 ALDH1A1 (0.48) MAPTKDM4ELMNAKMT2AALDH1A1
SCHEMBL7643303 0.69 NPSR1 (0.42) MAPTKDM4ERXFP1NPSR1KMT2A
SCHEMBL7640473 0.69 ALDH1A1 (0.49) LMNAKMT2AALDH1A1RAB9AMEN1
SCHEMBL7643249 0.69 ALDH1A1 (0.46) KMT2AGAAALDH1A1HPGDRAB9A
SCHEMBL6906325 0.69 LMNA (0.44) MAPTKDM4ELMNARXFP1PKM
SCHEMBL7643236 0.69 ALDH1A1 (0.49) LMNAKMT2AGAAALDH1A1HPGD
SCHEMBL7641003 0.69 ALDH1A1 (0.46) MAPTNPSR1KMT2AALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6683103-B2 SULFONAMIDES CONTAINING OXAZOLE AND SUBSTITUTED THIOPHENE RINGS, USEFUL FOR TREATING HYPERTENSION, CARDIOVASCULAR DISEASE, ASTHMA, PULMONARY HYPERTENSION, INFLAMMATORY DISEASES, VISION DEFECTS, MENSTRUAL DISORDERS, RENAL FAILURE TEXAS BIOTECHNOLOGY CORPORATION 2004-01-27 — — US disclosed
US-6632829-B2 Thienyl, furyl and pyrrolyl-sulfonamides, useful for treating hypertension, cardiovascular disease, asthma, pulmonary hypertension, inflammatory diseases, vision defects, menstrual disorders, renal failure and other diseases TEXAS BIOTECHNOLOGY CORP. 2003-10-14 — — US disclosed
US-6613804-B2 Treatment of hypertension, cardiovascular disease, pulmonary hypertension, erythropoietin-mediated vasoconstriction, endotoxin shock, pulmonary hypertension, anaphylactic shock and hemorrhagic shock ENCYSIVE PHARMACEUTICALS, INC. 2003-09-02 — — US disclosed
US-6458805-B2 ANTAGONISTS; ESPECIALLY SODIUM SALTS TEXAS BIOTECHNOLOGY CORPORATION 2002-10-01 — — US disclosed
US-6432994-B1 CARDIOVASCULAR DISORDERS, GLAUCOMA; ANTIINFLAMMATORY, WOUND HEALING, HYPOTENSIVE, ANTIASTHMATIC, AND ANTIANAPHYLACTIC AGENTS TEXAS BIOTECHNOLOGY CORPORATION 2002-08-13 — — US disclosed
US-6342610-B2 COMPOUNDS SUCH AS N-(4-BROMO-3-METHYL-5-ISOXAZOLYL)-2-N-BENZYLBENZO(B)THIOPHENE-3-SUFONAMIDE ADMINISTERED AS ENDOTHELIN PEPTIDE RECEPTOR ANTAGONISTS TEXAS BIOTECHNOLOGY CORP. 2002-01-29 — — US disclosed
US-6331637-B1 N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin TEXAS BIOTECHNOLOGY CORPORATION 2001-12-18 — — US disclosed
US-6248767-B1 VASOCONSTRICTION TEXAS BIOTECHNOLOGY CORP. 2001-06-19 — — US disclosed