SCHEMBL7647360

SCHEMBL7647360

CCCC#Cc1cc(F)c(Br)cc1F

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 1/20 0.36
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22748831 0.88 KCNH2 (0.37) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL5099937 0.77 ACACB (0.40) TLR8
SCHEMBL7651081 0.74 CYP2D6 (0.36) TLR8CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL17525545 0.74 ALDH1A1 (0.33)
SCHEMBL31633771 0.71 ACACB (0.39) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL8978869 0.71 ACACB (0.39) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL19384848 0.70 ACACB (0.41) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL8978862 0.69 ACACB (0.38) CYP1A2CYP2D6CYP2C9CYP2C19NPSR1
SCHEMBL15353223 0.68 TLR8 (0.45) TLR8CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL19403081 0.67 HSD17B10 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0530338-B1 ANISOTROPIC ORGANIC COMPOUNDS QINETIQ LTD (GB) 2002-05-02 EP disclosed
US-5888421-A LIQUID CRYSTALS THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 1999-03-30 US disclosed