Heptane

Heptane

SCHEMBL7647372

CC(C)O.CCCCCCC.CCO.O=C(O)C(F)(F)F

nearest known ligand 0.50

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Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Heptane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FAAH O00519 8/20 0.50
CES2 O00748 6/20 0.50
CES1 P23141 5/20 0.50
MEN1 O00255 1/20 0.50
CYP1A2 P05177 1/20 0.50
KMT2A Q03164 1/20 0.50
HSD17B10 Q99714 1/20 0.50
EPHX1 P07099 1/20 0.46
GPR84 Q9NQS5 3/20 0.45
FFAR1 O14842 1/20 0.45
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL28015086 0.98 FAAH (0.48) FAAHCES2CES1MEN1CYP1A2
Heptane SCHEMBL3918420 0.96 FAAH (0.54) FAAHCES2CES1MEN1CYP1A2
Decane SCHEMBL6353937 0.96 FAAH (0.54) FAAHCES2CES1MEN1CYP1A2
Trifluoroacetic Acid SCHEMBL3673750 0.94 FAAH (0.52) FAAHCES2CES1MEN1CYP1A2
Trifluoroacetic Acid SCHEMBL28128351 0.91 FAAH (0.50) FAAHCES2CES1MEN1CYP1A2
Heptane SCHEMBL1776021 0.91 FAAH (0.58) FAAHCES2CES1MEN1CYP1A2
Trifluoroacetic Acid SCHEMBL5880385 0.89 FAAH (0.56) FAAHCES2CES1MEN1CYP1A2
Trifluoroacetic Acid SCHEMBL7647467 0.89 TP53 (0.36) FAAHCES2CES1MEN1CYP1A2
Trifluoroacetic Acid SCHEMBL28824297 0.89 FAAH (0.41) FAAHCES2CES1MEN1CYP1A2
Trifluoroacetic Acid SCHEMBL28392985 0.89 FAAH (0.41) FAAHCES2CES1MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6479519-B1 INHIBITORS OF CELL ADHESION; TREATMENT OF ASTHMA OR INFLAMMATORY BOWEL DISEASE AVENTIS PHARMA LIMITED (GB) 2002-11-12 US disclosed