Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.44 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5017861 | 1.00 | HRH1 (0.44) | HRH1HDAC6MEN1LMNAGLA | |
| Fumaric Acid SCHEMBL7647905 | 1.00 | HRH1 (0.44) | HRH1HDAC6MEN1LMNAGLA | |
| Fumaric Acid SCHEMBL5017856 | 1.00 | HRH1 (0.44) | HRH1HDAC6MEN1LMNAGLA | |
| SCHEMBL4862162 | 0.88 | HRH1 (0.49) | HRH1HDAC6DRD2DRD4CREBBP | |
| SCHEMBL4863503 | 0.76 | HRH1 (0.49) | HRH1HDAC6DRD2DRD4CREBBP | |
| SCHEMBL14197429 | 0.74 | HRH1 (0.52) | HRH1HDAC6DRD2GAA | |
| SCHEMBL14197457 | 0.70 | HRH1 (0.49) | HRH1HDAC6DRD2DRD4CREBBP | |
| SCHEMBL11359103 | 0.68 | HRH1 (0.58) | HRH1HDAC6DRD2DRD4CREBBP | |
| SCHEMBL14197432 | 0.67 | HRH1 (0.48) | HRH1HDAC6SMN1; SMN2DRD2DRD4 | |
| SCHEMBL4872282 | 0.67 | HRH1 (0.48) | HRH1HDAC6SMN1; SMN2DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479534-B1 | Indoline derivatives and method of treating obesity | VERNALIS RESEARCH LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |