Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652026 | 0.88 | AKR1C3 (0.40) | ALDH1A1MEN1KMT2ANPSR1LMNA | |
| SCHEMBL7650742 | 0.81 | MEN1 (0.42) | ALDH1A1MEN1KMT2AMCOLN3NPSR1 | |
| SCHEMBL7655761 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AMCOLN3NPSR1 | |
| SCHEMBL7652054 | 0.79 | MEN1 (0.40) | ALDH1A1MEN1KMT2AMCOLN3NPSR1 | |
| SCHEMBL7652765 | 0.79 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AMCOLN3NPSR1 | |
| SCHEMBL8119583 | 0.79 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AMCOLN3NPSR1 | |
| SCHEMBL7653880 | 0.77 | MEN1 (0.39) | ALDH1A1MEN1KMT2AMCOLN3NPSR1 | |
| SCHEMBL8126427 | 0.75 | CYP3A4 (0.47) | ALDH1A1MEN1KMT2ANPSR1USP2 | |
| SCHEMBL7951448 | 0.74 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AMCOLN3NPSR1 | |
| SCHEMBL8124267 | 0.74 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AMCOLN3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | claimed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | claimed |
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |