SCHEMBL7649592

SCHEMBL7649592

C[Si](C)(C=Cc1ccccc1)C=Cc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.50
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
CHAT P28329 2/20 0.44
ALDH1A1 P00352 5/20 0.43
KDM4E B2RXH2 3/20 0.43
HPGD P15428 3/20 0.43
TRPA1 O75762 2/20 0.43
RELA Q04206 1/20 0.43
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
GLA P06280 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
NFE2L2 Q16236 1/20 0.42
CYP19A1 P11511 1/20 0.42
MAOA P21397 1/20 0.42
LMNA P02545 1/20 0.42
ALOX5 P09917 1/20 0.42
MAPK1 P28482 1/20 0.42
GRM5 P41594 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14946408 1.00 MAOB (0.50) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL9650544 0.87 ALDH1A1 (0.56) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL1826881 0.86 ALDH1A1 (0.42) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL1826879 0.86 ALDH1A1 (0.42) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL373962 0.84 MAOB (0.50) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL5845622 0.84 MAOB (0.50) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL23200493 0.82 MAOB (0.48) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL23200492 0.82 MAOB (0.48) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL15087175 0.81 RELA (0.47) MEN1KMT2AALDH1A1KDM4EHPGD
SCHEMBL2051056 0.80 MAOB (0.46) MAOBMEN1KMT2ACHATALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136874-A Microporous polymeric foams made with silicon or germanium based monomers THE PROCTER & GAMBLE COMPANY (US) 2000-10-24 US claimed
EP-0948560-B1 MICROPOROUS POLYMERIC FOAMS MADE WITH SILICON OR GERMANIUM BASED MONOMERS PROCTER & GAMBLE (US) 2002-08-14 EP disclosed
US-6136874-A Microporous polymeric foams made with silicon or germanium based monomers THE PROCTER & GAMBLE COMPANY (US) 2000-10-24 US disclosed
EP-0948560-A1 MICROPOROUS POLYMERIC FOAMS MADE WITH SILICON OR GERMANIUM BASED MONOMERS THE PROCTER & GAMBLE COMPANY (US) 1999-10-13 EP disclosed
WO-1998029486-A1 MICROPOROUS POLYMERIC FOAMS MADE WITH SILICON OR GERMANIUM BASED MONOMERS THE PROCTER & GAMBLE COMPANY (US) 1998-07-09 WO disclosed