Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650378 | 0.90 | MEN1 (0.43) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL7650388 | 0.89 | CHKA (0.41) | MAPTSMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL607069 | 0.84 | LMNA (0.60) | ALDH1A1LMNAMAPK1HTTMAPT | |
| SCHEMBL7649894 | 0.84 | MEN1 (0.49) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL7653796 | 0.81 | MAPT (0.50) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL7653466 | 0.78 | LMNA (0.65) | ALDH1A1TSHRLMNAMAPK1HTT | |
| SCHEMBL7648451 | 0.76 | TP53 (0.42) | ALDH1A1MAPTSMN1; SMN2TP53CACNA1G | |
| SCHEMBL7652383 | 0.76 | LMNA (0.50) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL7646684 | 0.76 | MAPT (0.48) | ALDH1A1LMNAMAPK1HTTMAPT | |
| SCHEMBL7649700 | 0.75 | LMNA (0.59) | ALDH1A1LMNAMAPK1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | disclosed |