Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | GHSR | Q92847 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647493 | 0.92 | MAPT (0.49) | LMNANR1I2ADORA3CNR1HRH1 | |
| SCHEMBL7649700 | 0.88 | LMNA (0.59) | LMNAGAAMAPK1HTTMEN1 | |
| SCHEMBL7649894 | 0.86 | MEN1 (0.49) | LMNAGAAMAPK1HTTMEN1 | |
| SCHEMBL7648593 | 0.86 | GPR183 (0.44) | LMNANR1I2ADORA3CNR1HRH1 | |
| SCHEMBL7646684 | 0.84 | MAPT (0.48) | LMNAKCNH2GAAMAPK1HTT | |
| SCHEMBL7653466 | 0.84 | LMNA (0.65) | LMNAGAAMAPK1HTTMEN1 | |
| SCHEMBL7650388 | 0.82 | CHKA (0.41) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL7649923 | 0.81 | ALDH1A1 (0.49) | LMNAMAPK1MEN1KMT2AMAPT | |
| SCHEMBL7653796 | 0.80 | MAPT (0.50) | LMNAGAAMAPK1HTTMEN1 | |
| SCHEMBL7651629 | 0.80 | LMNA (0.50) | LMNAGAAOPRD1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | disclosed |