Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.64 |
| ▸ | POLB | P06746 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1593927 | 0.85 | KMT2A (0.60) | KMT2APOLBALDH1A1MEN1S1PR3 | |
| SCHEMBL25202900 | 0.79 | TRPV1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2838920 | 0.77 | HDAC4 (0.54) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15962680 | 0.76 | TRPV1 (0.52) | KMT2AALDH1A1MEN1L3MBTL1KDM1A | |
| SCHEMBL14669483 | 0.75 | ALDH1A1 (0.63) | KMT2APOLBALDH1A1MEN1MAPT | |
| SCHEMBL20057529 | 0.74 | TRPV1 (0.51) | KMT2AALDH1A1MEN1KDM1AMAPT | |
| SCHEMBL20323596 | 0.73 | TRPV1 (0.50) | KMT2APOLBALDH1A1MEN1KDM1A | |
| SCHEMBL1383257 | 0.73 | POLB (1.00) | KMT2APOLBMEN1S1PR3L3MBTL1 | |
| SCHEMBL7657327 | 0.72 | POLB (0.65) | KMT2APOLBALDH1A1MEN1S1PR3 | |
| SCHEMBL1594391 | 0.72 | KMT2A (0.66) | KMT2APOLBALDH1A1MEN1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |