Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654933 | 0.84 | MAPT (0.51) | MAPTGAATP53HTTLMNA | |
| SCHEMBL7653796 | 0.84 | MAPT (0.50) | KDM4EMAPTGAARAB9ATP53 | |
| SCHEMBL7647493 | 0.83 | MAPT (0.49) | MAPTGAATP53HTTLMNA | |
| SCHEMBL609438 | 0.83 | MEN1 (0.63) | KDM4EALDH1A1MAPTUSP2GAA | |
| SCHEMBL7649914 | 0.83 | IGF1R (0.47) | KDM4EALDH1A1MAPTGAATP53 | |
| SCHEMBL7650324 | 0.82 | MAPT (0.47) | KDM4EALDH1A1MAPTGAATP53 | |
| SCHEMBL7649585 | 0.82 | MAPT (0.47) | MAPTGAATP53HTTLMNA | |
| SCHEMBL7646684 | 0.82 | MAPT (0.48) | KDM4EALDH1A1MAPTGAATP53 | |
| SCHEMBL7651313 | 0.80 | KMT2A (0.44) | KDM4EALDH1A1MAPTMCHR1TP53 | |
| SCHEMBL7651244 | 0.79 | SIGMAR1 (0.44) | KDM4EALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | disclosed |