Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MPO | P05164 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648336 | 1.00 | HSD17B10 (0.67) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7654811 | 0.95 | HSD17B10 (0.71) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7648358 | 0.90 | KDM4E (0.67) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7651742 | 0.84 | HSD17B10 (0.52) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7651736 | 0.83 | HSD17B10 (0.52) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E | |
| SCHEMBL13332558 | 0.83 | CYP1A2 (0.62) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7649974 | 0.82 | MAPK10 (0.55) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7650071 | 0.81 | KDM4E (0.58) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E | |
| SCHEMBL10830938 | 0.81 | TNF (0.58) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7651129 | 0.80 | CA12 (0.51) | HSD17B10MAPK10SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |