Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | TNF | P01375 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648336 | 0.95 | HSD17B10 (0.67) | HSD17B10MAPTKDM4EMAPK1MAPK10 | |
| SCHEMBL7649673 | 0.95 | HSD17B10 (0.67) | HSD17B10MAPTKDM4EMAPK1MAPK10 | |
| SCHEMBL7648358 | 0.93 | KDM4E (0.67) | HSD17B10MAPTKDM4EMAPK1MAPK10 | |
| SCHEMBL10830938 | 0.85 | TNF (0.58) | HSD17B10MAPTKDM4EMAPK1MAPK10 | |
| SCHEMBL13332558 | 0.85 | CYP1A2 (0.62) | HSD17B10MAPTKDM4EMAPK1MAPK10 | |
| SCHEMBL7650071 | 0.83 | KDM4E (0.58) | HSD17B10MAPTKDM4EMAPK1MAPK10 | |
| SCHEMBL5406225 | 0.82 | HSD17B10 (1.00) | HSD17B10MAPTKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL7651742 | 0.81 | HSD17B10 (0.52) | HSD17B10MAPTKDM4EMAPK1MAPK10 | |
| SCHEMBL2861287 | 0.81 | MPO (0.62) | HSD17B10MAPTKDM4EMAPK1MAPK10 | |
| SCHEMBL7651736 | 0.81 | HSD17B10 (0.52) | HSD17B10MAPTKDM4EMAPK10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |